ω-Conotoxin GVIA
Catalog No：CP-GVIA-001B
Manufacturer：CPC Scientific
Size：1 mg
CAS No.：106375-28-4
Formula：C120H182 N38O43S 6
MWt：3,037
€376,00
| Product Name: | ω-Conotoxin GVIA |
| Category: | Peptides |
| Three letter sequence: | Cys-Lys-Ser- Hyp-Gly-Ser- Ser-Cys-Ser- Hyp-Thr-Ser- Tyr-Asn-Cys- Cys-Arg-Ser- Cys-Asn- Hyp-Tyr-Thr- Lys-Arg-Cys- Tyr- NH2(Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26 Bridge) |
| One letter sequence: | CKS-Hyp- GSSCS-Hyp- TSYNCCRSCN- Hyp-YTKRCY- NH2(Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26 Bridge) |
| Description: | ω-Conotoxin GVIA from the venom of the fish-hunting cone snail Conus geographus efficiently blocks N- type calcium channels. This presynaptic inhibition of calcium influx prevents the voltage- activated release of acetylcholine. |
| Literature References: | B.M.Olivera et al., Biochemistry, 23, 5087 (1984) B.M.Olivera et al., Biochemistry, 26, 2086 (1987) J.Rivier et al., J. Biol. Chem., 262, 1194 (1987) D.R.Hillyard et al., Neuron, 9, 69 (1992) K.Sato et al., Biochem. Biophys. Res. Commun., 194, 1292 (1993) J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994) |
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