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Western blot analysis of extracts of various cell lines, using XBP1s antibody (A17007) at 1:1000 dilution.HeLa cells were treated by Tunicamycin (2 μg/mL) for 8 hours.C6 cells were treated by Tunicamycin (2 μg/mL) for 8 hours.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 10s.
XBP1s Rabbit pAb
Catalog No：AB-A17007
Manufacturer：ABclonal
Synonyms：XBP1;TREB-5;TREB5;XBP-1;XBP2;XBP1s;CBX1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €325,00
| Product Name: | XBP1s Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-376 of human XBP1s (NP_001073007.1). |
| Gene ID: | 7494 |
| Swiss prot: | P17861 |
| Molecular weight: | 28kDa/40kDa |
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