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Western blot analysis of extracts of Jurkat cells, using VAV1 antibody (A15108) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
VAV1 Rabbit pAb
Catalog No：AB-A15108
Manufacturer：ABclonal
Synonyms：VAV1;VAV
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | VAV1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human VAV1 (NP_005419.2). |
| Gene ID: | 7409 |
| Swiss prot: | P15498 |
| Molecular weight: | 94kDa/98kDa |
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