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Western blot analysis of extracts of HepG2 cells, using USP20 antibody (A14643) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
USP20 Rabbit pAb
Catalog No：AB-A14643
Manufacturer：ABclonal
Synonyms：USP20;LSFR3A;VDU2;hVDU2
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | USP20 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human USP20 (NP_006667.3). |
| Gene ID: | 10868 |
| Swiss prot: | Q9Y2K6 |
| Molecular weight: | 102kDa |
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