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Western blot analysis of extracts of various cell lines, using USP2 antibody (A10399) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 1s.
USP2 Rabbit pAb
Catalog No：AB-A10399
Manufacturer：ABclonal
Synonyms：USP2;UBP41;USP9
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | USP2 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-430 of human USP2 (NP_004196.4). |
| Gene ID: | 9099 |
| Swiss prot: | O75604 |
| Molecular weight: | 40kDa/41kDa/45kDa/68kDa |
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