SB297006 [Cas No. 58816-69-6]
Catalog No:TA-T4674
Manufacturer:TargetMol
CAS No.:58816-69-6
Formula:C18H18N2O5
MWt:342.4
€70,00 – €678,00
Name: | SB 297006 |
Category: | Biochemicals |
Description: | SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3, IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg). |
Pathway: | Immunology & Inflammation,Microbiology & Virology |
Target: | CCR |
Receptor: | CCR3 |
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