Brevilin A [Cas No. 16503-32-5]
Catalog No:TA-T4672
Manufacturer:TargetMol
CAS No.:16503-32-5
Formula:C20H26O5
MWt:346.41
€192,00 – €2.430,00
Name: | Brevilin A |
Category: | Biochemicals |
Description: | Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour |
Pathway: | Angiogenesis, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Microbiology & Virology |
Target: | Antifection,JAK,STAT |
Receptor: | Antifection,JAK,STAT |
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