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Western blot analysis of extracts of mouse pancreas, using TYROBP antibody (A14794) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
TYROBP Rabbit pAb
Catalog No：AB-A14794
Manufacturer：ABclonal
Synonyms：TYROBP;DAP12;KARAP;PLOSL
Applications：WB
Reactivity：Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | TYROBP Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TYROBP (NP_003323.1). |
| Gene ID: | 7305 |
| Swiss prot: | O43914 |
| Molecular weight: | 11kDa/12kDa |
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