PX-12 [Cas No. 141400-58-0]
Catalog No：TA-T2283
Manufacturer：TargetMol
Synonyms：PX 12,PX-12,IV-2
CAS No.：141400-58-0
Formula：C7H12N2S2
MWt：188.32
€52,00 – €943,00
| Name: | PX12 |
| Category: | Biochemicals |
| Description: | PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival. |
| Pathway: | Metabolism |
| Target: | Thioredoxin inhibitor |
| Receptor: | TRX (HT-29 cells), TRX (MCF-7) |
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