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Western blot analysis of extracts of K562 cells, using TPMT antibody (A1017) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
TPMT Rabbit pAb
Catalog No：AB-A1017
Manufacturer：ABclonal
Synonyms：TPMT;TPMTD
Applications：WB,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | TPMT Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1). |
| Gene ID: | 7172 |
| Swiss prot: | P51580 |
| Molecular weight: | 28kDa |
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