TLR3 Rabbit pAb
Catalog No：AB-A1449
Manufacturer：ABclonal
Synonyms：TLR3;CD283;IIAE2
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €325,00
| Product Name: | TLR3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 740-904 of human TLR3 (NP_003256.1). |
| Gene ID: | 7098 |
| Swiss prot: | O15455 |
| Molecular weight: | 72kDa/103kDa |
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