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Western blot analysis of extracts of various cell lines, using Staufen antibody (A4131) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
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Immunohistochemistry of paraffin-embedded human esophagus using Staufen antibody (A4131) at dilution of 1:100 (40x lens).
Staufen Rabbit pAb
Catalog No：AB-A4131
Manufacturer：ABclonal
Synonyms：STAU1;PPP1R150;STAU
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Staufen Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5’UTR. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 426-577 of human Staufen (NP_059347.2). |
| Gene ID: | 6780 |
| Swiss prot: | O95793 |
| Molecular weight: | 54kDa/55kDa/63kDa |
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