Trichostatin A [Cas No. 58880-19-6]
Catalog No:TA-T6270
Manufacturer:TargetMol
Synonyms:TSA
CAS No.:58880-19-6
Formula:C17H22N2O3
MWt:302.4
€56,00 – €1.289,00
Name: | Trichostatin A |
Category: | Biochemicals |
Description: | Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. |
Pathway: | Chromatin/Epigenetic, DNA Damage/DNA Repair, NF-Κb |
Target: | HDAC inhibitor |
Receptor: | HDAC |
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