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Western blot analysis of extracts of 293T cells, using SPRY3 antibody (A14669) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
SPRY3 Rabbit pAb
Catalog No：AB-A14669
Manufacturer：ABclonal
Synonyms：SPRY3;spry-3
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | SPRY3 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes. |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1). |
| Gene ID: | 10251 |
| Swiss prot: | O43610 |
| Molecular weight: | 31kDa |
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