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Western blot analysis of extracts of various cell lines, using SHP1 antibody (A1446) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
SHP1 Rabbit pAb
Catalog No：AB-A1446
Manufacturer：ABclonal
Synonyms：HCP;HCPH;HPTP1C;PTP-1C;SH-PTP1;SHP-1;SHP-1L;SHP1;CTCN6;PTPN6
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | SHP1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SHP1 (NP_002822.2). |
| Gene ID: | 5777 |
| Swiss prot: | P29350 |
| Molecular weight: | 63kDa/67kDa/70kDa |
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