.jpg)
Western blot analysis of extracts of various cell lines, using SH2D1A antibody (A1143) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.
SH2D1A Rabbit pAb
Catalog No：AB-A1143
Manufacturer：ABclonal
Synonyms：SH2D1A;DSHP;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;XLP;XLPD;XLPD1
Applications：WB,IF
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | SH2D1A Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human SH2D1A (NP_002342.1). |
| Gene ID: | 4068 |
| Swiss prot: | O60880 |
| Molecular weight: | 6kDa/8kDa/13kDa/14kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No：AB-A0175
Manufacturer：ABclonal
Synonyms：PIM;PIM1;PIM1
Applications：WB
Reactivity：Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0122
Manufacturer：ABclonal
Synonyms：INPP5D;SHIP;SHIP-1;SHIP1;SIP-145;hp51CN;p150Ship
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0068
Manufacturer：ABclonal
Synonyms：BCR;ALL;BCR1;CML;D22S11;D22S662;PHL
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0038
Manufacturer：ABclonal
Synonyms：BRAF;B-RAF1;B-raf;BRAF1;NS7;RAFB1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0024
Manufacturer：ABclonal
Synonyms：FADK;FAK;FAK1;FRNK;PPP1R71;p125FAK;pp125FAK;PTK2
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €295,00
Catalog No：AB-A0008
Manufacturer：ABclonal
Synonyms：10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1;PTEN;PTENbeta
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00