SH2D1A Rabbit pAb
Catalog No:AB-A1143
Manufacturer:ABclonal
Synonyms:SH2D1A;DSHP;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;XLP;XLPD;XLPD1
Applications:WB,IF
Reactivity:Human,Mouse
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | SH2D1A Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human SH2D1A (NP_002342.1). |
Gene ID: | 4068 |
Swiss prot: | O60880 |
Molecular weight: | 6kDa/8kDa/13kDa/14kDa |
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