Aftin-4 [Cas No. 866893-90-5]
Catalog No：TA-T4364
Manufacturer：TargetMol
Synonyms：Aftin 4,Aftin-4
CAS No.：866893-90-5
Formula：C20H28N6O
MWt：368.48
€41,00 – €1.343,00
| Name: | Aftin4 |
| Category: | Biochemicals |
| Description: | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer’s disease-like toxicity in the rodent brain. |
| Pathway: | Neuroscience |
| Target: | Gamma-secretase agonist |
| Receptor: | γ secretase(Aβ42) |
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