Aftin-4 [Cas No. 866893-90-5]
Catalog No:TA-T4364
Manufacturer:TargetMol
Synonyms:Aftin 4,Aftin-4
CAS No.:866893-90-5
Formula:C20H28N6O
MWt:368.48
€41,00 – €1.343,00
Name: | Aftin4 |
Category: | Biochemicals |
Description: | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer’s disease-like toxicity in the rodent brain. |
Pathway: | Neuroscience |
Target: | Gamma-secretase agonist |
Receptor: | γ secretase(Aβ42) |
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