β,β-Dimethylacrylshikonin [Cas No. 24502-79-2]
Catalog No：TA-T3S2344
Manufacturer：TargetMol
Synonyms：β, β-Dimethylacrylshikonin
CAS No.：24502-79-2
Formula：C21H22O6
MWt：370.4
€70,00 – €167,00
| Name: | Dimethylacrylshikonin |
| Category: | Biochemicals |
| Description: | 1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. |
| Pathway: | MAPK |
| Target: | ERK |
| Receptor: | ERK |
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