RGD-targeted Proapoptotic Peptide
Catalog No：CP-RGDP-009
Manufacturer：CPC Scientific
Size：1 mg
MWt：2,707
€388,00
| Product Name: | RGD-targeted Proapoptotic Peptide |
| Category: | Peptides |
| Three letter sequence: | Ala-Cys-Asp- Cys-Arg-Gly- Asp-Cys- Phe-Cys-Gly- Gly-DLys- DLeu-DAla- DLys-DLeu- DAla-DLys- DLys-DLeu- DAla-DLys- DLeu-DAla- DLys-NH2 (S-S bonded C1-C4 & C2- C3) |
| One letter sequence: | ACDCRGDCFC- GG- klaklakklaklak- NH2 (S-S bonded C1-C4 & C2-C3) |
| Description: | This sequence is a targeted proapoptotic peptide. The C- terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D- amino acids. |
| Literature References: | Lahdenranta, J. et al. FASEB J. 10.1096/fj.07- 8273com (2007); Ellerby, H. et al. Nat. Med. 5, 1032 (1999); Smolarczyk, R. et al. Acta Biochim. Pol. 53, 801 (2006); Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002). |
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