RGD-4C
Catalog No：CP-THRO-005A
Manufacturer：CPC Scientific
Size：1 mg
Formula：C42H60N 14O16S4
MWt：1,145
€294,00
| Product Name: | RGD-4C |
| Category: | Peptides |
| Three letter sequence: | Ala-Cys-Asp- Cys-Arg-Gly- Asp-Cys- Phe-Cys-Gly (Disulfide bridge: 2-10 and 4-8) |
| One letter sequence: | ACDCRGDCFC G (Disulfide bridge: 2-10 and 4-8) |
| Description: | This peptide, a double cyclic peptide, binds preferentially to integrins at sites of tumor angiogenesis and inflammed synovium in-vivo, and can be internalized into targeted cells. RGD-4C is a double cyclic peptide that can bind preferentially to integrins at sites of tumor angiogenesis and inflamed synovium in vivo, and can be internalized into targeted cells. Novel applications include the coupling of RGD- 4C to proapoptotic domains to treat tumors and |
| Literature References: | Curnis, F. et al. Cancer Res. 64, 565 (2004) Su, Z. et al. Bioconjug. Chem. 13, 561 (2002) Gerlag, M. et al. Arthritis Res. 3, 357 (2001) Ellerby, H. et al. Nature Med. 5, 1032 (1999); |
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