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Western blot analysis of extracts of THP-1 cells, using RASGRP1 antibody (A10495) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 30s.
RASGRP1 Rabbit pAb
Catalog No：AB-A10495
Manufacturer：ABclonal
Synonyms：RASGRP1;CALDAG-GEFI;CALDAG-GEFII;RASGRP;V;hRasGRP1
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | RASGRP1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_005730.2). |
| Gene ID: | 10125 |
| Swiss prot: | O95267 |
| Molecular weight: | 55kDa/62kDa/68kDa/86kDa/90kDa |
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