RANKL Rabbit pAb
Catalog No:AB-A2550
Manufacturer:ABclonal
Synonyms:TNFSF11;CD254;ODF;OPGL;OPTB2;RANKL;TNLG6B;TRANCE;hRANKL2;sOdf
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | RANKL Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human RANKL (NP_003692.1). |
Gene ID: | 8600 |
Swiss prot: | O14788 |
Molecular weight: | 27kDa/30kDa/35kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No:AB-A0175
Manufacturer:ABclonal
Synonyms:PIM;PIM1;PIM1
Applications:WB
Reactivity:Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0166
Manufacturer:ABclonal
Synonyms:VASP
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €295,00
Catalog No:AB-A0121
Manufacturer:ABclonal
Synonyms:BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €485,00
Catalog No:AB-A0082
Manufacturer:ABclonal
Synonyms:FGFR1;BFGFR;CD331;CEK;ECCL;FGFBR;FGFR-1;FLG;FLT-2;FLT2;HBGFR;HH2;HRTFDS;KAL2;N-SAM;OGD;bFGF-R-1
Applications:WB
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0068
Manufacturer:ABclonal
Synonyms:BCR;ALL;BCR1;CML;D22S11;D22S662;PHL
Applications:WB,IHC
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Catalog No:AB-A0033
Manufacturer:ABclonal
Synonyms:TNFRSF1A;CD120a;FPF;TBP1;TNF-R;TNF-R-I;TNF-R55;TNFAR;TNFR1;TNFR55;TNFR60;p55;p55-R;p60
Applications:IF
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €370,00