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Western blot analysis of extracts of various cell lines, using RANKL antibody (A16326) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5min.
RANKL Rabbit pAb
Catalog No：AB-A16326
Manufacturer：ABclonal
Synonyms：TNFSF11;CD254;ODF;OPGL;OPTB2;RANKL;TNLG6B;TRANCE;hRANKL2;sOdf
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | RANKL Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human RANKL (NP_003692.1). |
| Gene ID: | 8600 |
| Swiss prot: | O14788 |
| Molecular weight: | 27kDa/30kDa/35kDa |
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