Atosiban acetate [Cas No. 914453-95-5]
Catalog No：TA-T5148
Manufacturer：TargetMol
Synonyms：RW22164,RWJ22164
CAS No.：914453-95-5
Formula：C45H71N11O14S2
MWt：1054.24
€80,00 – €695,00
| Name: | Atosiban acetate (90779-69-4 free base) |
| Category: | Biochemicals |
| Description: | Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence. |
| Pathway: | GPCR/G Protein |
| Target: | Oxytocin Receptor |
| Receptor: | Others |
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