Western blot analysis of extracts of HepG2 cells, using PTPN12 antibody (A20569) at 1:500 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 90s.
PTPN12 Rabbit pAb
Catalog No:AB-A20569
Manufacturer:ABclonal
Synonyms:PTPG1; PTP-PEST
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€125,00 – €370,00
Product Name: | PTPN12 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Immunogen: | Recombinant protein of human PTPN12. |
Gene ID: | 5782 |
Swiss prot: | Q05209 |
Molecular weight: | 88kDa |
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