Western blot analysis of extracts of various cell lines, using PSEN2 antibody (A7719) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
PSEN2 Rabbit pAb
Catalog No:AB-A7719
Manufacturer:ABclonal
Synonyms:PSEN2;AD3L;AD4;CMD1V;PS2;STM2
Applications:WB,IHC,IF
Reactivity:Human,Mouse,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | PSEN2 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | Alzheimer’s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. |
Immunogen: | Recombinant protein of human PSEN2. |
Gene ID: | 5664 |
Swiss prot: | P49810 |
Molecular weight: | 46kDa/50kDa |
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