.jpg)
Western blot analysis of extracts of U-87MG cells, using Presenilin 1 antibody (A2187) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 30s.
.jpg)
Immunohistochemistry of paraffin-embedded human liver using Presenilin 1 Rabbit pAb (A2187) at dilution of 1:100 (40x lens).
Presenilin 1 Rabbit pAb
Catalog No：AB-A2187
Manufacturer：ABclonal
Synonyms：AD3;FAD;PS-1;PS1;S182;Presenilin 1;PSEN1
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | Presenilin 1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | Alzheimer’s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Presenilin 1 (NP_015557.2). |
| Gene ID: | 5663 |
| Swiss prot: | P49768 |
| Molecular weight: | 21kDa/42kDa/46kDa/48kDa/52kDa |
Help & Support
Product
Guarantee and
Expert Support
Related products
Catalog No：AB-A0146
Manufacturer：ABclonal
Synonyms：SLC9A3R1;EBP50;NHERF;NHERF-1;NHERF1;NPHLOP2
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0106
Manufacturer：ABclonal
Synonyms：MCPH12, PLSTIRE
Applications：WB
Reactivity：Human,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
Catalog No：AB-A0079
Manufacturer：ABclonal
Synonyms：FGF1;AFGF;ECGF;ECGF-beta;ECGFA;ECGFB;FGF-1;FGF-alpha;FGFA;GLIO703;HBGF-1;HBGF1
Applications：WB
Reactivity：Mouse
Host：Rabbit
Conjugate：No
€65,00 – €325,00
Catalog No：AB-A0067
Manufacturer：ABclonal
Synonyms：MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
Catalog No：AB-A0076
Manufacturer：ABclonal
Synonyms：BDPLT16;BDPLT2;CD61;GP3A;GPIIIa;GT;Integrin beta 3;ITGB3
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
Catalog No：AB-A0027
Manufacturer：ABclonal
Synonyms：CANDF7;IMD31A;IMD31B;IMD31C;ISGF-3;STAT91;STAT1 alpha;STAT1
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00