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Western blot analysis of extracts of various cell lines, using Presenilin 1 antibody (A19103) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 3min.
Presenilin 1 Rabbit mAb
Catalog No：AB-A19103
Manufacturer：ABclonal
Synonyms：AD3;FAD;PS-1;PS1;S182;Presenilin 1;PSEN1
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €485,00
| Product Name: | Presenilin 1 Rabbit mAb |
| Category: | Monoclonal Antibodies |
| Description: | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] |
| Immunogen: | A synthesized peptide derived from human Presenilin 1 |
| Gene ID: | 5663 |
| Swiss prot: | P49768 |
| Molecular weight: | 28kDa |
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