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Western blot analysis of extracts of various cell lines, using PP2A-B55β/PR55β/PP2A-B55β/PR55β/PPP2R2B antibody (A10494) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
PP2A-B55β/PR55β/PPP2R2B Rabbit pAb
Catalog No：AB-A10494
Manufacturer：ABclonal
Synonyms：PPP2R2B;B55BETA;PP2AB55BETA;PP2ABBETA;PP2APR55B;PP2APR55BETA;PR2AB55BETA;PR2ABBETA;PR2APR55BETA;PR52B;PR55-BETA;PR55BETA;SCA12
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | PP2A-B55β/PR55β/PPP2R2B Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5′ UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human PP2A-B55β/PR55β/PP2A-B55β/PR55β/PPP2R2B (NP_858060.2). |
| Gene ID: | 5521 |
| Swiss prot: | Q00005 |
| Molecular weight: | 50kDa/51kDa/52kDa/58kDa/62kDa |
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