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Western blot analysis of extracts of various cell lines, using Phospho-ULK1-S467 antibody (AP1262) at 1:1000 dilution.HeLa and Jurkat cells were treated by Serum-starvation overnight at 37℃.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Enhanced Kit (RM00021).|Exposure time: 180s.
Phospho-ULK1-S467 Rabbit pAb
Catalog No：AB-AP1262
Manufacturer：ABclonal
Synonyms：ULK1;ATG1;ATG1A;UNC51;Unc51.1;hATG1;ULk1
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-ULK1-S467 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165). |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S467 of human ULK1 |
| Gene ID: | 8408 |
| Swiss prot: | O75385 |
| Molecular weight: | 112kDa |
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