Phospho-MLKL-S358 Rabbit pAb
Catalog No：AB-AP1244
Manufacturer：ABclonal
Synonyms：MLKL; hMLKL; mixed lineage kinase domain-like protein
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-MLKL-S358 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S358 of human MLKL. |
| Gene ID: | 197259 |
| Swiss prot: | Q8NB16 |
| Molecular weight: | 53kDa/54kDa |
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