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Immunofluorescence analysis of U2OS cells using Phospho-MET-Y1349 antibody (AP0077). Blue: DAPI for nuclear staining.
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Western blot analysis of extracts of HeLa cells, using Phospho-MET-Y1349 antibody (AP0077) at 1:1000 dilution. HeLa cells were treated by HGF (40ng/mL) for 10 minutes after serum-starvation overnight.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Phospho-MET-Y1349 Rabbit pAb
Catalog No：AB-AP0077
Manufacturer：ABclonal
Synonyms：MET;AUTS9;DFNB97;HGFR;RCCP2;c-Met
Applications：WB,IHC,IF
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-MET-Y1349 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Immunogen: | A synthetic phosphorylated peptide around Y1349 of human MET (NP_000236.2). |
| Gene ID: | 4233 |
| Swiss prot: | P08581 |
| Molecular weight: | 85kDa/155kDa/157kDa |
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