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Immunofluorescence analysis of U2OS cells using Phospho-MET-Y1234 antibody (AP0078). Blue: DAPI for nuclear staining.
Phospho-MET-Y1234 Rabbit pAb
Catalog No：AB-AP0078
Manufacturer：ABclonal
Synonyms：MET;AUTS9;DFNB97;HGFR;RCCP2;c-Met
Applications：WB,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-MET-Y1234 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Immunogen: | A synthetic phosphorylated peptide around Y1234 of human MET (NP_000236.2). |
| Gene ID: | 4233 |
| Swiss prot: | P08581 |
| Molecular weight: | 85kDa/155kDa/157kDa |
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