Phospho-MAP2K3-S189/MAP2K6-S207 Rabbit pAb
Catalog No：AB-AP0066
Manufacturer：ABclonal
Synonyms：MAP2K3/MAP2K6
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-MAP2K3-S189/MAP2K6-S207 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S189 of human MAP2K3 and S207 of human MAP2K6 |
| Gene ID: | 5606/5608 |
| Swiss prot: | P46734/P52564 |
| Molecular weight: | 36kDa/39kDa/31kDa/37kDa |
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