Phospho-LIMK1-T508/LIMK2-T505 Rabbit pAb
Catalog No：AB-AP0566
Manufacturer：ABclonal
Synonyms：LIMK1/LIMK2
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-LIMK1-T508/LIMK2-T505 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] |
| Immunogen: | A synthetic phosphorylated peptide around T508 of human LIMK1 (NP_002305.1). |
| Gene ID: | 3984/3985 |
| Swiss prot: | P53667/P53671 |
| Molecular weight: | 33kDa/68kDa/70kDa/72kDa/69kDa/77kDa |
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