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Western blot analysis of extracts of various cell lines, using Phospho-JNK1/2-T183/Y185 antibody (AP0473) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.
Phospho-JNK1/2-T183/Y185 Rabbit pAb
Catalog No：AB-AP0473
Manufacturer：ABclonal
Synonyms：JNK1/2
Applications：WB
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-JNK1/2-T183/Y185 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] |
| Immunogen: | A synthetic phosphorylated peptide around T183 of human JNK1 (NP_620637.1). |
| Gene ID: | 5599/5601 |
| Swiss prot: | P45983/P45984 |
| Molecular weight: | 35kDa/44kDa/48kDa/27kDa |
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