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Western blot analysis of extracts of various cell lines, using Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb (AP0863) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb
Catalog No：AB-AP0863
Manufacturer：ABclonal
Synonyms：INSR/IGF1R
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| Immunogen: | A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R. |
| Gene ID: | 3643/3480 |
| Swiss prot: | P06213/P08069 |
| Molecular weight: | 155kDa |
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