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Western blot analysis of extracts of HeLa cells, using Phospho-FADD-S194 pAb (AP1054) at 1:1000 dilution or FADD antibody (A5819).Hela cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.HeLa cells were treated by nocodazole (50 ng/mL) at 37℃ for 20 hours.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 60s.
Phospho-FADD-S194 Rabbit pAb
Catalog No：AB-AP1054
Manufacturer：ABclonal
Synonyms：GIG3;MORT1;FADD;FADD
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-FADD-S194 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S194 of human FADD. |
| Gene ID: | 8772 |
| Swiss prot: | Q13158 |
| Molecular weight: | 23kDa |
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