Phospho-ERBB2-Y1248 Rabbit pAb
Catalog No：AB-AP0581
Manufacturer：ABclonal
Synonyms：ERBB2;CD340;HER-2;HER-2/neu;HER2;MLN 19;NEU;NGL;TKR1;erb-b2 receptor tyrosine kinase 2;HER2/ErbB2;ErbB2;MLN19
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-ERBB2-Y1248 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
| Immunogen: | A synthetic phosphorylated peptide around Y1248 of human ERBB2 (NP_004439.2). |
| Gene ID: | 2064 |
| Swiss prot: | P04626 |
| Molecular weight: | 62kDa/70kDa/97kDa/134kDa/136kDa/137kDa |
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