Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb
Catalog No:AB-AP0328
Manufacturer:ABclonal
Synonyms:CDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1;p27 KIP 1
Applications:WB,IHC
Reactivity:Human
Host:Rabbit
Conjugate:No
€150,00 – €410,00
Product Name: | Phospho-CDKN1B/p27KIP1-T187 Rabbit pAb |
Category: | Phosphorylated Antibodies |
Description: | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
Immunogen: | A phospho specific peptide corresponding to residues surrounding T187 of human CDKN1B/p27KIP1 |
Gene ID: | 1027 |
Swiss prot: | P46527 |
Molecular weight: | 22kDa |
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