Phospho-CBL-Y731 Rabbit pAb
Catalog No:AB-AP1073
Manufacturer:ABclonal
Synonyms:C-CBL;CBL2;FRA11B;NSLL;RNF55;CBL;c-Cbl
Applications:WB
Reactivity:Human
Host:Rabbit
Conjugate:No
€65,00 – €410,00
Product Name: | Phospho-CBL-Y731 Rabbit pAb |
Category: | Phosphorylated Antibodies |
Description: | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
Immunogen: | A phospho synthetic peptide corresponding to residues surrounding Y731 of human CBL. |
Gene ID: | 867 |
Swiss prot: | P22681 |
Molecular weight: | 99kDa |
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