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Western blot analysis of extracts of Jurkat cells, using Phospho-CBL-Y700 antibody (AP0780) at 1:2000 dilution or CBL antibody (A0732). Jurkat cells were treated by Pervanadate (1 mM) at 37℃ for 30 minutes. |Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
Phospho-CBL-Y700 Rabbit pAb
Catalog No：AB-AP0780
Manufacturer：ABclonal
Synonyms：C-CBL;CBL2;FRA11B;NSLL;RNF55;CBL;c-Cbl
Applications：WB
Reactivity：Human
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-CBL-Y700 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5′ UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Immunogen: | A synthetic phosphorylated peptide around Y700 of human CBL (NP_005179.2). |
| Gene ID: | 867 |
| Swiss prot: | P22681 |
| Molecular weight: | 99kDa |
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