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Western blot analysis of extracts of HT-29 cells, using Phospho-BRCA1-S1423 antibody (AP0232) at 1:2000 dilution. HT-29 cells were treated by Anisomycin (5ug/mL) for 30 minutes after serum-starvation overnight.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 5s.
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Immunohistochemistry of paraffin-embedded rat testis using Phospho-BRCA1-S1423 antibody (AP0232) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human breast cancer using Phospho-BRCA1-S1423 antibody (AP0232) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse testis using Phospho-BRCA1-S1423 antibody (AP0232) at dilution of 1:100 (40x lens).
Phospho-BRCA1-S1423 Rabbit pAb
Catalog No：AB-AP0232
Manufacturer：ABclonal
Synonyms：BRCA1;BRCAI;BRCC1;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;PSCP;RNF53
Applications：WB,IHC,IF
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-BRCA1-S1423 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
| Immunogen: | A synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1). |
| Gene ID: | 672 |
| Swiss prot: | P38398 |
| Molecular weight: | 7kDa/78-85kDa/202-210kDa |
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