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Western blot analysis of extracts of K562 cells, using Phospho-BCR-Y177 antibody (AP0606) at 1:1000 dilution. K562 cell lysate were treated by CIP (20ul CIP for each 400ul cell lysate) at 37℃ for 1 hour .|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
Phospho-BCR-Y177 Rabbit pAb
Catalog No：AB-AP0606
Manufacturer：ABclonal
Synonyms：BCR;ALL;BCR1;CML;D22S11;D22S662;PHL
Applications：WB
Reactivity：Human,Mouse
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-BCR-Y177 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. |
| Immunogen: | A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3). |
| Gene ID: | 613 |
| Swiss prot: | P11274 |
| Molecular weight: | 137kDa/142kDa |
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