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Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-Androgen Receptor-S650 antibody (AP0307).
Phospho-Androgen Receptor-S650 Rabbit pAb
Catalog No：AB-AP0307
Manufacturer：ABclonal
Synonyms：AIS;AR8;DHTR;HUMARA;HYSP1;KD;NR3C4;SBMA;SMAX1;TFM;AR
Applications：IHC
Reactivity：Human
Host：Rabbit
Conjugate：No
€150,00 – €410,00
| Product Name: | Phospho-Androgen Receptor-S650 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S650 of human AR |
| Gene ID: | 367 |
| Swiss prot: | P10275 |
| Molecular weight: | 44kDa/67kDa/99kDa |
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