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Western blot analysis of extracts of C6 cells, using Phospho-ABL1-Y412 pAb (AP1060) at 1:1000 dilution or ABL1 antibody (A0282).C6 cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% BSA.|Detection: ECL Basic Kit (RM00020).|Exposure time: 3s.
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Immunohistochemistry of paraffin-embedded rat kidney using Phospho-ABL1-Y412 antibody (AP1060) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded human appendix using Phospho-ABL1-Y412 antibody (AP1060) at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded mouse liver using Phospho-ABL1-Y412 antibody (AP1060) at dilution of 1:100 (40x lens).
Phospho-ABL1-Y412 Rabbit pAb
Catalog No：AB-AP1060
Manufacturer：ABclonal
Synonyms：ABL;JTK7;p150;c-ABL;v-abl;CHDSKM;c-ABL1;ABL1;c-Abl;bcr/abl
Applications：WB,IHC
Reactivity：Human,Mouse,Rat
Host：Rabbit
Conjugate：No
€65,00 – €410,00
| Product Name: | Phospho-ABL1-Y412 Rabbit pAb |
| Category: | Phosphorylated Antibodies |
| Description: | This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1. |
| Gene ID: | 25 |
| Swiss prot: | P00519 |
| Molecular weight: | 123kDa |
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