Pep-1L-NOTA
Catalog No：CP-CANS-012A
Manufacturer：CPC Scientific
Size：1 mg
Formula：C84H139 N27O25S 3
MWt：2,023
€2.826,00
| Product Name: | Pep-1L-NOTA |
| Category: | Peptides |
| Three letter sequence: | H-Ala-Cys- Gly-Glu-Met- Gly-Trp-Val- Arg-Cys-Gly- Gly-Gly-Ser- C6-Lys- Lys(NOTA)- NH2 (trifluoroacet ate salt) (Reduced Cys-H) |
| One letter sequence: | ACGEMGWVR CGGGS-C6-K- K(NOTA)-NH2 |
| Description: | Metal chelating peptide Pep-1L- NOTA targets tumor- restricted receptor, IL13RA2, found to be present in some aggressive malignancies, specifically gliomas and malignant melanoma. Recent work has demonstrated that the copper-bound peptide selectively binds hIL13RA2- expressing tumors and validates its use in peptide-based PET imaging for cancer diagnostics. |
| Literature References: | Sai, Kiran Kumar Solingapuram, et al. “Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker.” Oncotarget 5 (2017). |
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