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Western blot analysis of extracts of rat brain, using PCSK1 antibody (A12237) at 1:3000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
PCSK1 Rabbit pAb
Catalog No：AB-A12237
Manufacturer：ABclonal
Synonyms：PCSK1;BMIQ12;NEC1;PC1;PC3;SPC3
Applications：WB
Reactivity：Rat
Host：Rabbit
Conjugate：No
€65,00 – €370,00
| Product Name: | PCSK1 Rabbit pAb |
| Category: | Polyclonal Antibodies |
| Description: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human PCSK1 (NP_000430.3). |
| Gene ID: | 5122 |
| Swiss prot: | P29120 |
| Molecular weight: | 79kDa/84kDa |
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