Western blot analysis of extracts of various cell lines, using PAX5 antibody (A12048) at 1:1000 dilution.|Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.|Lysates/proteins: 25ug per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit (RM00020).|Exposure time: 90s.
PAX5 Rabbit pAb
Catalog No:AB-A12048
Manufacturer:ABclonal
Synonyms:PAX5;ALL3;BSAP
Applications:WB
Reactivity:Human,Rat
Host:Rabbit
Conjugate:No
€65,00 – €370,00
Product Name: | PAX5 Rabbit pAb |
Category: | Polyclonal Antibodies |
Description: | This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PAX5 (NP_057953.1). |
Gene ID: | 5079 |
Swiss prot: | Q02548 |
Molecular weight: | 31kDa/32kDa/34kDa/35kDa/37kDa/38kDa/42kDa |
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