Crenigacestat [Cas No. 1421438-81-4]
Catalog No：TA-T3633
Manufacturer：TargetMol
Synonyms：LY3039478
CAS No.：1421438-81-4
Formula：C22H23F3N4O4
MWt：464.44
€55,00 – €1.182,00
| Name: | Crenigacestat |
| Category: | Biochemicals |
| Description: | LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment. |
| Pathway: | Neuroscience, Proteases & Proteasome, Stem Cells |
| Target: | Gamma-secretase inhibitor |
| Receptor: | Notch-1 |
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